Pre-loader

Mitrajit Ghosh

About


Research Interests: Vascular Biology, Neurodegenerative Diseases, Tumor microenvironment, Tissue Regeneration, Intravital Imaging and Nano-science

Academic Qualifications


  • Ph.D  (Dr.rer.nat.), IMCAR, RWTH Aachen, Germany
  • Postdoctoral Fellow, Institute for Stroke and Dementia Research, LMU Munich, Germany
  • Feodor-Lynen Postdoctoral Fellow, Harvard Medical School, MGH, Boston, USA

Research Statement


Vascular Biology group would contribute and compliment understanding in health and disease pathophysiology. The main interests are in neurodegenerative diseases, aging, tumor microenvironment and tissue regeneration, where the focus will be in addressing the cellular components and blood vessel physiology in terms of structural and functional contribution in homeostasis. These devastating diseases are formidable challenges in clinic. There is an unmet need to conduct research to understand, and combat therapy resistance and improve patient survival.
Along with these, we are interested in nanoscience, bio-engineering and safety & health engineering, for development and application of smart products.

Latest Publications


  • 1 Seano G, Nia H.T, Emblem K.E., Datta M, Ren J, Kloepper J, Krishnan S, Ghosh M, Pinho M.C., Askoxylakis V, Ferraro G.B., Riedemann L, Gerstner E.R., Batchelor T.T., Wen P.Y., Lin N.U., Grodzinsky A.J., Fukumura D, Huang P, Baish J.W., Padera T.P., Munn L.L., Jain R.K., Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium, 3, 230, Nature Biomedical Engineering, 2019
  • 2 Griveau A, Seano G, Shelton S J, Kupp R, Jahangiri A, Obernier K, Krishnan S, Lindberg O R, Yuen T J, Tien A C, Sabo J K, Wang N, Chen I, Kloepper J, Larrouquere L, Ghosh M, Tirosh I, Huillard E, Alvarez-Buylla A, Oldham M C, Persson A I, Weiss W A, Batchelor T T, Stemmer-Rachamimov A, Suva M L, Phillips J J, Aghi M, Mehta S, Jain R K and Rowitch D H, A Glial Signature and Wnt7 Signalling Regulate Glioma-Vascular Interactions and Tumor Microenvironment, 33, 874, Cancer Cell, 2018
  • 3 Pakhira B, Ghosh M, Allam A and Sarkar S, Carbon Nano Onions Cross Blood Brain Barrier, 6, 29779, RSC Advances, 2016
  • 4 Ghosh, M., Balbi, M., Hellal, F., Dichgans, M., Lindauer, U. and Plesnila, N., Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, 78, 887, Annals of Neurology, 2015
  • 5 Balbi M, Ghosh M, Longden T, Jativa M, Gesierich B, Lourbopoulos A, Hellal F, Nelson M and Plesnila N, Dysfunction of mouse cerebral arteries during early aging, 35, 1445, Journal of Cerebral Blood Flow and Metabolism, 2015
  • 6 Wijnands KA, Hoeksema MA, Meesters DM, van den Akker NM, Molin DG, Briede JJ, Ghosh M, Kohler SE, van Zandvoort MA, de Winther MP, Buurman WA, Lamers WH, Poeze M, Arginase-1 Deficiency Regulates Arginine Concentrations and NOS2-Mediated NO Production during Endotoxemia, 9, 86135, PloS One, 2014
  • 7 Lemmens KJ, van de Wier B, Vaes N, Ghosh M, van Zandvoort MA, van der Vijgh WJ, Bast A, Haenen GR, The flavonoid 7-mono-O-(ß-hydroxyethyl)-rutoside is able to protect endothelial cells by a direct antioxidant effect, 28, 538, Toxicology In Vitro, 2014
  • 8 Ghosh M*, van den Akker NMS, Wijnands KAP, Poeze M, Weber C, McQuade LE, Pluth MD, Lippard SJ, Post MJ, Molin DGM and Zandvoort MAMJ, Specific Visualization of Nitric Oxide in the Vasculature with Two-Photon Microscopy Using a Copper Based Fluorescent Probe, 8, 75331, PloS One, 2013
  • 9 KAP Wijnands, NMS van den Akker, M Ghosh, DM Meesters, JJ Briede, ES Kohler, MAMJ van Zandvoort, WH Lamers, DGM Molin, M Poeze, ENDOTHELIAL-SPECIFIC ARGININOMICCINATE-SYNTHETASE KNOCKOUT MICE HAVE IMPAIRED ARGININE DE NOVO SYNTHESIS. NO PRODUCTION AND MICROCIRCULATION DURING ENDOTOXEMIA, 38, S226, Intensive Care Medicine, 2012
  • 10 Sonkar S.K., Ghosh M, Roy M, Begum A and Sarkar S, Carbon nano-onions as nontoxic and high performance fluorescing agents in food chain an in vivo study from unicellular Escherichia coli to multicellular Caenorhabditis elegans, 2, 105, Materials Express, 2012
  • View More

    Research Areas


    • Nanocoating of PPE for advanced antimicrobial efficacy
    • Nanotechnology for developing smart airbag
    • Dextran micro-beads incorporated 3D chitosan-collagen-fibrinogen (CCF) scaffold for skin tissue engineering

    Publications


    1 Seano G, Nia H.T, Emblem K.E., Datta M, Ren J, Kloepper J, Krishnan S, Ghosh M, Pinho M.C., Askoxylakis V, Ferraro G.B., Riedemann L, Gerstner E.R., Batchelor T.T., Wen P.Y., Lin N.U., Grodzinsky A.J., Fukumura D, Huang P, Baish J.W., Padera T.P., Munn L.L., Jain R.K., Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium, 3, 230, Nature Biomedical Engineering, 2019 2 Griveau A, Seano G, Shelton S J, Kupp R, Jahangiri A, Obernier K, Krishnan S, Lindberg O R, Yuen T J, Tien A C, Sabo J K, Wang N, Chen I, Kloepper J, Larrouquere L, Ghosh M, Tirosh I, Huillard E, Alvarez-Buylla A, Oldham M C, Persson A I, Weiss W A, Batchelor T T, Stemmer-Rachamimov A, Suva M L, Phillips J J, Aghi M, Mehta S, Jain R K and Rowitch D H, A Glial Signature and Wnt7 Signalling Regulate Glioma-Vascular Interactions and Tumor Microenvironment, 33, 874, Cancer Cell, 2018 3 Pakhira B, Ghosh M, Allam A and Sarkar S, Carbon Nano Onions Cross Blood Brain Barrier, 6, 29779, RSC Advances, 2016 4 Ghosh, M., Balbi, M., Hellal, F., Dichgans, M., Lindauer, U. and Plesnila, N., Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, 78, 887, Annals of Neurology, 2015 5 Balbi M, Ghosh M, Longden T, Jativa M, Gesierich B, Lourbopoulos A, Hellal F, Nelson M and Plesnila N, Dysfunction of mouse cerebral arteries during early aging, 35, 1445, Journal of Cerebral Blood Flow and Metabolism, 2015 6 Wijnands KA, Hoeksema MA, Meesters DM, van den Akker NM, Molin DG, Briede JJ, Ghosh M, Kohler SE, van Zandvoort MA, de Winther MP, Buurman WA, Lamers WH, Poeze M, Arginase-1 Deficiency Regulates Arginine Concentrations and NOS2-Mediated NO Production during Endotoxemia, 9, 86135, PloS One, 2014 7 Lemmens KJ, van de Wier B, Vaes N, Ghosh M, van Zandvoort MA, van der Vijgh WJ, Bast A, Haenen GR, The flavonoid 7-mono-O-(ß-hydroxyethyl)-rutoside is able to protect endothelial cells by a direct antioxidant effect, 28, 538, Toxicology In Vitro, 2014 8 Ghosh M*, van den Akker NMS, Wijnands KAP, Poeze M, Weber C, McQuade LE, Pluth MD, Lippard SJ, Post MJ, Molin DGM and Zandvoort MAMJ, Specific Visualization of Nitric Oxide in the Vasculature with Two-Photon Microscopy Using a Copper Based Fluorescent Probe, 8, 75331, PloS One, 2013 9 Sonkar S.K., Ghosh M, Roy M, Begum A and Sarkar S, Carbon nano-onions as nontoxic and high performance fluorescing agents in food chain an in vivo study from unicellular Escherichia coli to multicellular Caenorhabditis elegans, 2, 105, Materials Express, 2012 10 Ghosh, M., Sonkar, S. K., Saxena, M. and Sarkar, S, Carbon Nano-onions for Imaging the Life Cycle of Drosophila Melanogaster, 7, 3170, Small, 2011
  • 1 KAP Wijnands, NMS van den Akker, M Ghosh, DM Meesters, JJ Briede, ES Kohler, MAMJ van Zandvoort, WH Lamers, DGM Molin, M Poeze, ENDOTHELIAL-SPECIFIC ARGININOMICCINATE-SYNTHETASE KNOCKOUT MICE HAVE IMPAIRED ARGININE DE NOVO SYNTHESIS. NO PRODUCTION AND MICROCIRCULATION DURING ENDOTOXEMIA, 38, S226, Intensive Care Medicine, 2012
  • 2 MAMJ van Zandvoort, M Ghosh, T Rademaekers, E Biessen, S Heeneman, NMS van den Akker, DGM Molin, M Poeze, N Wijnands, MJ Post, Intravital microscopy of microvasculature in atherosclerosis, 48, 4, Journal of Vascular Research, 2011
  • 3 M Ghosh, NMS van den Akker, C Weber, M.J.Post, DGM Molin, MAMJ van Zandvoort, Specific visualization of nitric oxide in cells and arteries with a copper based fluorescent probe and two-photon microscopy, 48, 4, Journal of Vascular Research, 2011
  • 4 M Ghosh, NMS van den Akker, C Weber, DGM Molin, MAMJ van Zandvoort, Direct imaging and visualization of nitric oxide in cells and arteries with a copper (II) fluorescent probe and two-photon microscopy, 24, S17, Nitric Oxide, 2011
  • 5 M. Ghosh, N. M. S. V. D. Akker, C. Weber, D. G. M. Molin, M. A. M. J. V. Zandvoort, IMAGING OF NITRIC OXIDE DIRECTLY IN CELLS AND ARTERIES WITH A COPPER (II) FLUORESCENT PROBE AND TWO-PHOTON MICROSCOPY, 12, 175, Atherosclerosis Supplement, 2011
  • Patents


    # Patents Year

    Member


    Vipul Kumar
    Ramanna Reddy
    Suparna Majumder

    Responsibilities


    Convener (Departmental Faculty Committee)
    2019-

    Projects


    • Developing Functional Skin Construct with Embedded Pericytes: Potential for Vascularization, Sponsored
      Ongoing

    Awards


    • Merit Certificate (St.Josephs College, Bangalore), Year: 2003
    • Summer School Honorarium Fellow (NIAS, IISC, Bangalore), Year: 2006
    • Travel Award (Gordon Research Conference & Seminar), Italy, Year: 2012
    • Travel Award (EMBO Meeting, Israel) [SyNergy, Munich], Year: 2013
    • Travel Award (SyNergy, Munich), Year: 2015
    • EuCAR-IRTG PhD Scholarship (DFG, Germany), Year: 2008
    • Feodor-Lynen Postdoctoral Fellowship (Alexander von Humboldt Foundation, Germany), Year: 2016

    Citations


    Google Scholar
    CITATION H-INDEX I-10 INDEX
    418 10 10

    Created: 23 November 2019