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    Manas Kumar Ghosh

    About


    I am an inorganic chemist with research interest in biomimetic, bioinorganic, bioorganic, biosynthesis, and enzymology.

    Academic Qualifications


    Assistant Professor and HOD, Sovarani Memorial College (University of Calcutta), India (2023-2025)

    Postdoctoral Research Associate, Texas A & M University, USA (2019-2023)

    Postdoctoral Research Associate, Harvard University, USA (2017-2019)

    Postdoctoral Research Associate, Pennsylvania State University, USA (2014-2017)

    Ph.D. in Chemistry, Tata Institute of Fundamental Research, Mumbai, India (2008-2014)

    M.Sc. in Chemistry, Indian Institute of Engineering Science and Technology, Shibpur, India (2006-2008)

    Research Statement


    Protein biochemistry, Biosynthesis, Bioinorganic chemistry, Bioorganic chemistry, Enzymology, Structure-function relationships of (metallo)enzymes, Stopped-flow kinetics, Mass spectrometry, EPR, Proton coupled electron transfer (PCET).

    Latest Publications


  • 1 Manas K Ghosh, Frank M Raushel, Biosynthesis of UDP-a-N-Acetyl-d-mannosaminuronic Acid and CMP-b-N-Acetyl-d-neuraminic Acid for the Capsular Polysaccharides of Campylobacter jejuni., 63, 688-698, Biochemistry, 2024
  • 2 Manas K. Ghosh, Tamari Narindoshvili, James B. Thoden, Mitchell E. Schumann, Hazel M. Holden, Frank M. Raushel, Biosynthesis of CDP-6-D-Glucitol for the Capsular Polysaccharides of Campylobacter jejuni., 63, 699-710, Biochemistry, 2024
  • 3 Dao Feng Xiang, Maggie Xu, Manas K. Ghosh, Frank M. Raushel, Metabolic Pathways for the Biosynthesis of Heptoses Used in the Construction of Capsular Polysaccharides in the Human Pathogen Campylobacter jejuni., 62, 3145-3158, Biochemistry, 2023
  • 4 Manas K. Ghosh, Dao Feng Xiang, Frank M. Raushel, Biosynthesis of 3,6-dideoxy-heptoses for the Capsular Polysaccharides of Campylobacter jejuni., 62, 1287–1297, Biochemistry, 2023
  • 5 Dao Feng Xiang, Manas K. Ghosh, Alexander S. Riegert, James B. Thoden, Hazel M. Holden, Frank M. Raushel, Bifunctional Epimerase/Reductase Enzymes Facilitate the Modulation of 6-Deoxy-Heptoses Found in the Capsular Polysaccharides of Campylobacter jejuni., 62, 134-144, Biochemistry, 2023
  • 6 Manas K. Ghosh, Dao Feng Xiang, Frank M. Raushel, Product Specificity of the C4-Reductases in the Biosynthesis of GDP-6-deoxy-heptoses During Capsular Polysaccharide Formation in Campylobacter jejuni., 61, 2138-2147, Biochemistry, 2022
  • 7 Manas K. Ghosh, Dao Feng Xiang, James B. Thoden, Hazel M. Holden, Frank M. Raushel, C3- and C3/C5-Epimerases Required for the Biosynthesis of the Capsular Polysaccharides from Campylobacter jejuni., 61, 2036-2048, Biochemistry, 2022
  • 8 Andreas Meyer, Annemarie Kehl, Chang Cui, Fehmke A K Reichardt, Fabian Hecker, Lisa-Marie Funk, Manas K Ghosh, Kuan-Ting Pan, Henning Urlaub, Kai Tittmann, JoAnne Stubbe, Marina Bennati, 19F Electron-Nuclear Double Resonance Reveals Interaction between Redox-Active Tyrosines across the a/b Interface of E. coli Ribonucleotide Reductase., 144, 11270–11282, J. Am. Chem. Soc., 2022
  • 9 Dao Feng Xiang, James B. Thoden, Manas K. Ghosh, Hazel M. Holden, Frank M. Raushel, Reaction Mechanism and Three-Dimensional Structure of GDP-D-glycero-a-D-manno-heptose 4,6-Dehydratase from Campylobacter jejuni., 61, 1313–1322, Biochemistry, 2022
  • 10 Shachin Patra, Cheng-Wei Lin, Manas K Ghosh, Steven M Havens, Seth A Cory, David H Russell, David P Barondeau, Recapitulating the frataxin activation mechanism in an engineered bacterial cysteine desulfurase supports the architectural switch model., bioRxiv, 2020
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    Publications


  • 1 Manas K Ghosh, Frank M Raushel, Biosynthesis of UDP-a-N-Acetyl-d-mannosaminuronic Acid and CMP-b-N-Acetyl-d-neuraminic Acid for the Capsular Polysaccharides of Campylobacter jejuni., 63, 688-698, Biochemistry, 2024
  • 2 Manas K. Ghosh, Tamari Narindoshvili, James B. Thoden, Mitchell E. Schumann, Hazel M. Holden, Frank M. Raushel, Biosynthesis of CDP-6-D-Glucitol for the Capsular Polysaccharides of Campylobacter jejuni., 63, 699-710, Biochemistry, 2024
  • 3 Dao Feng Xiang, Maggie Xu, Manas K. Ghosh, Frank M. Raushel, Metabolic Pathways for the Biosynthesis of Heptoses Used in the Construction of Capsular Polysaccharides in the Human Pathogen Campylobacter jejuni., 62, 3145-3158, Biochemistry, 2023
  • 4 Manas K. Ghosh, Dao Feng Xiang, Frank M. Raushel, Biosynthesis of 3,6-dideoxy-heptoses for the Capsular Polysaccharides of Campylobacter jejuni., 62, 1287–1297, Biochemistry, 2023
  • 5 Dao Feng Xiang, Manas K. Ghosh, Alexander S. Riegert, James B. Thoden, Hazel M. Holden, Frank M. Raushel, Bifunctional Epimerase/Reductase Enzymes Facilitate the Modulation of 6-Deoxy-Heptoses Found in the Capsular Polysaccharides of Campylobacter jejuni., 62, 134-144, Biochemistry, 2023
  • 6 Manas K. Ghosh, Dao Feng Xiang, Frank M. Raushel, Product Specificity of the C4-Reductases in the Biosynthesis of GDP-6-deoxy-heptoses During Capsular Polysaccharide Formation in Campylobacter jejuni., 61, 2138-2147, Biochemistry, 2022
  • 7 Manas K. Ghosh, Dao Feng Xiang, James B. Thoden, Hazel M. Holden, Frank M. Raushel, C3- and C3/C5-Epimerases Required for the Biosynthesis of the Capsular Polysaccharides from Campylobacter jejuni., 61, 2036-2048, Biochemistry, 2022
  • 8 Andreas Meyer, Annemarie Kehl, Chang Cui, Fehmke A K Reichardt, Fabian Hecker, Lisa-Marie Funk, Manas K Ghosh, Kuan-Ting Pan, Henning Urlaub, Kai Tittmann, JoAnne Stubbe, Marina Bennati, 19F Electron-Nuclear Double Resonance Reveals Interaction between Redox-Active Tyrosines across the a/b Interface of E. coli Ribonucleotide Reductase., 144, 11270–11282, J. Am. Chem. Soc., 2022
  • 9 Dao Feng Xiang, James B. Thoden, Manas K. Ghosh, Hazel M. Holden, Frank M. Raushel, Reaction Mechanism and Three-Dimensional Structure of GDP-D-glycero-a-D-manno-heptose 4,6-Dehydratase from Campylobacter jejuni., 61, 1313–1322, Biochemistry, 2022
  • 10 Shachin Patra, Cheng-Wei Lin, Manas K Ghosh, Steven M Havens, Seth A Cory, David H Russell, David P Barondeau, Recapitulating the frataxin activation mechanism in an engineered bacterial cysteine desulfurase supports the architectural switch model., bioRxiv, 2020
  • 11 Hannah R Rose#, Manas K Ghosh#, Ailiena O Maggiolo, Christopher J Pollock, Elizabeth J Blaesi, Viviane Hajj, Yifeng Wei, Lauren J Rajakovich, Wei-chen Chang, Yilin Han, Mariana Hajj, Carsten Krebs, Alexey Silakov, Maria-Eirini Pandelia, J Martin Bollinger Jr, Amie K Boal (# Equal first authors), Structural basis for superoxide activation of Flavobacterium johnsoniae class I ribonucleotide reductase and for radical initiation by its dimanganese cofactor., 57, 2679-2693, Biochemistry, 2018
  • 12 Manas Kumar Ghosh, Priyanka Basak, Shyamalava Mazumdar, Mechanism of copper incorporation in subunit II of cytochrome c oxidase from Thermus thermophilus: identification of intermediate species., 52, 4620-4635, Biochemistry, 2013
  • 13 Manas Kumar Ghosh, Jitumani Rajbongshi, Debajani Basumatary, Shyamalava Mazumdar, Role of the surface-exposed leucine 155 in the metal ion binding loop of the CuA domain of cytochrome c oxidase from Thermus thermophilus on the function and stability of the protein., 2443-2452, 51, Biochemistry, 2012
  • 14 Jitumani Rajbongshi, Manas Kumar Ghosh, Nusrat JM Sanghamitra, Sayan Gupta, Shyamalava Mazumdar, Conformational properties of the bis-m-(thiolato) dicopper center in cytochrome c oxidase., 51, 83-98, Indian J Chem A, 2012

    • Patents


    # Patents Year

    Research Groups


    Pratali Chakraborty
    M. Sc.
    2025chm007.pratali@students.iiests.ac.in

    Research:
    Synthesis of inhibitors for lipoxygenase

    Shubhankar Batabyal
    M. Sc.
    2025chm035.shubhankar@students.iiests.ac.in

    Research:
    Synthesis of inhibitors for myo-inositol oxygenase

    Created: 23 November 2019