I am a structural biologist by training and passion. I received my Ph.D. in structural biology (protein X-ray crystallography) in 2015 from Indian Institute of Technology Kharagpur (Supervisor: Prof. Amit Kumar Das, Department of Biotechnology) for my work on how conformational dynamics of bi-domain enzymes are intertwined with its catalytic mechanism. I worked at The University of Oxford (Radcliffe Department of Medicine) as a postdoctoral scientist to decipher the role of transcriptional regulation in the early stage of hematopoietic development. Before that, I was at Ecole Polytechnique Paris, France (Laboratoire de Biologie Structurale de la Cellule) as a CNRS postdoctoral researcher and worked on determining the structure and function of protein complexes, involved in eukaryotic ribosome biogenesis and RNA modification.
M.Sc., Molecular Biology & Genetics, Presidency College, University of Calcutta (2008)
Ph.D. (Science), Protein X-Ray Crystallography, Indian Institute of Technology Kharagpur (2015)
Postdoctoral researcher, Laboratoire de Biologie Structurale de la Cellule (Graille Lab), France, Ecole Polytechnique - Institut Polytechnique de Paris - UMR7654 CNRS
Postdoctoral scientist, MRC Weatherall Institute of Molecular Medicine, Molecular haematology unit (Porcher Lab), Radcliffe Department of Medicine, University of Oxford
My current research area is structural biology and protein engineering. The team is working on,
- protein complexes involved in epitranscriptomic modification,
- discovering new targets for structure-based drug designing against cancer and fatal multi-drug resistant strains
- de novo drug designing
- scaffold-based vaccine designing
- studying conformational dynamics of protein and protein RNA complexes by molecular dynamics simulation and X-ray crystallography.
Motivated students are encouraged to contact for PhD /JRF positions.
Publications
1
Manisha Ganguly, Radhika Gupta, Amlan Roychowdhury, Ditipriya Hazra, De novo drug designing coupled with brute force screening and structure guided lead optimization gives highly specific inhibitor of METTL3: a potential cure for Acute Myeloid Leukaemia, 2, 1-4, Journal of Biomolecular Structure and Dynamics, 2023
2
Mitra, Anushka and Manna, Shibambika and Kundu, Raima and Hazra, Ditipriya and Roychowdhury, Amlan, Brute Force Virtual Drug Screening with Molecular Dynamics Simulation and MM/PBSA to Find Potent Inhibitors of METTL16, IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2023
3
Manna, Shibambika and Samal, Pragati and Basak, Rohini and Mitra, Anushka and Roy, Arijit Kumar and Kundu, Raima and Ahir, Amrita and Roychowdhury, Amlan and Hazra, Ditipriya, Amentoflavone and methyl hesperidin, novel lead molecules targeting epitranscriptomic modulator in acute myeloid leukemia: in silico drug screening and molecular dynamics simulation approach, 29, 9, Journal of Molecular Modeling, 2023
4
Bose, Madhuparna and Bhattacharyya, Sudipta and Biswas, Rupam and Roychowdhury, Amlan and Bhattacharjee, Atanu and Ghosh, Ananta Kumar and Das, Amit Kumar, Elucidation of the mechanism of disulfide exchange between staphylococcal thioredoxin2 and thioredoxin reductase2: A structural insight, 160, 1--13, Biochimie, 2019
5
Roychowdhury, Amlan and Joret, Clement and Bourgeois, Gabrielle and Heurgue-Hamard, Valerie and Lafontaine, Denis LJ and Graille, Marc, The DEAH-box RNA helicase Dhr1 contains a remarkable carboxyl terminal domain essential for small ribosomal subunit biogenesis, 47, 7548--7563, Nucleic acids research, 2019
6
Kundu, Anirban and Roychowdhury, Amlan and Bose, Madhuparna and Das, Amit Kumar and Ghosh, Ananta K, Reconstitution of the RNA-dependent RNA polymerase activity of Antheraea mylitta cypovirus in vitro using separately expressed different functional domains of the enzyme, 97, 1709--1719, Journal of General Virology, 2016
7
Roychowdhury, Amlan and Kundu, Anirban and Bose, Madhuparna and Gujar, Akanksha and Mukherjee, Somnath and Das, Amit Kumar, Complete catalytic cycle of cofactor-independent phosphoglycerate mutase involves a spring-loaded mechanism, 282, 1097--1110, The FEBS Journal, 2015
8
Roychowdhury, Amlan and Kundu, Anirban and Gujar, Akanksha and Bose, Madhuparna and Das, Amit Kumar, Expression, purification, crystallization and preliminary X-ray diffraction studies of phosphoglycerate mutase from Staphylococcus aureus NCTC8325, 70, 53--56, Acta Crystallographica Section F: Structural Biology Communications, 2014
9
Dutta, Debajyoti and Bhattacharyya, Sudipta and Roychowdhury, Amlan and Biswas, Rupam and Das, Amit Kumar, Crystal structure of hexanoyl-CoA bound to $eta$-ketoacyl reductase FabG4 of Mycobacterium tuberculosis, 450, 127--139, Biochemical Journal, 2013
10
Mukherjee, Somnath and Roychowdhury, Amlan and Dutta, Debajyoti and Das, Amit Kumar, Crystal structures of triosephosphate isomerase from methicillin resistant Staphylococcus aureus MRSA252 provide structural insights into novel modes of ligand binding and unique conformations of catalytic loop, 94, 2532--2544, Biochimie, 2012
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