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Manisha Ganguly

About


Designation: Research Scholar
Degree: Ph. D.
Supervisor: Amlan Roychowdhury

Academic Qualification

M.Sc. in Biotechnology


Research Area


Topic: Structural Biology and Protein Engineering

Understanding the dynamics of protein-nucleic acid interaction using X-ray crystal structures / Cryo-EM structures, and Molecular Dynamics Simulation.


Publications


Gupta, R., Ganguly, M., Jana, P., Roychowdhury, A. and Hazra, D., 2025. Two Birds with One Stone: Targeting Wild Type and Drug Resistant Mutant ALK Using Brute Force Screening, MD Simulation and NCI. IEEE Transactions on Computational Biology and Bioinformatics.

Rahman, S., Bhattacharya, A., Jana, P., Ganguly, M., Das, A.K., Hazra, D. and Roychowdhury, A., 2025. Subtractive proteomics unravel the potency of D-Alanine-D-Alanine Ligase as the drug target for Burkholderia pseudomallei. International Journal of Biological Macromolecules, p.144106.

Hazra, D., Rahman, S., Ganguly, M., Das, A.K. and Roychowdhury, A., 2025. Molecular dynamics simulation shows enhanced stability in scaffold-based macromolecule, designed by protein engineering: a novel methodology adapted for converting Mtb Ag85A to a multi-epitope vaccine. Journal of Molecular Modeling31(3), p.84.

Ganguly, M., Gupta, R., Roychowdhury, A. and Hazra, D., 2023. De novo drug designing coupled with brute force screening and structure guided lead optimization gives highly specific inhibitor of METTL3: a potential cure for Acute Myeloid Leukaemia. Journal of Biomolecular Structure and Dynamics, pp.1-14.